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Archive for December, 2009

 

 

The more alcohol an individual drinks, the more the risk of suicide grows, according to a researcher at Canada’s Center for Addiction and Mental Health (CAMH).

All Headline News reported Sept. 8 that CAMH senior researcher Robert Mann found that while suicide risk rose with alcohol consumption, as well as other factors like unemployment, the risk of suicide decreased when heavy drinkers joined Alcoholics Anonymous.

“These results suggest that a 1-liter increase in alcohol consumption led to an increase of 11 percent to 39 percent in suicides,” said Mann. “This observation is consistent with individual-level studies that show that heavy drinking, alcohol abuse and alcohol dependence increase a person’s risk of suicide substantially … However, it was heartening to see that increasing AA membership was related to reduced suicide mortality rates.”

The link between drinking and suicide was stronger among women than men, Mann noted.

          Night Falls Fast: Understanding Suicide
by Kay Redfield Jamison

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Benefits of Alcoholics Anonymous attendance

This study compared findings on the benefits associated with Alcoholics Anonymous (AA) attendance across 11 clinical sites in Project MATCH.

The largest benefit associated with AA attendance was increased abstinence, followed by reductions in alcohol-related consequences.

The magnitude of these benefits did not differ between sites.

A positive association was also found between AA attendance and increased purpose in life

A positive association was also found between AA attendance and increased purpose in life, but the size of this relationship was very small and was statistically significant only after controlling for measurement error.

Tonigan, J.S. Benefits of alcoholics anonymous attendance: Replication of findings between clinical research sites in Project MATCH. Alcoholism Treatment Quarterly, 19(1):67-78, 2001.

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angry manic man Antidepressant Induced Mania (ADM) Among People with Co-Occurring Disorders (COD). Sometimes, informally called Bipolar III disorder.

A recent study of medical charts at a bipolar specialty clinic gives new support to the idea that antidepressants can induce mania in some bipolar patients.

For some time, clinicians have been concerned about the problem of antidepressant-induced mania (ADM), but most research has not supported the connection between antidepressants and manic or hypomanic episodes.

This study looked at ADM and examined differences between patients with bipolar disorder and a substance use disorder (SUD) and patients without SUD.

The article presents solid evidence for a significantly increased risk of ADM in patients with co-occurring bipolar disorder and SUD. The article also comments about why the increased risk to these clients may not have been identified in prior research.

Manwani and colleagues investigated medical charts from 98 patients who were treated at a bipolar clinic between 2000 and 2004. These patients accounted for 335 antidepressant trials during that period. Of the sample, 55 patients (accounting for 184 of the trials) had a lifetime history of a SUD.

For this study, an episode of ADM was defined as hypomanic or manic symptoms within 12 weeks of beginning a new antidepressant medication.

There were some substantial differences between patients who did and did not have a SUD history—e.g., clients with SUD were almost twice as likely as those without SUD to be prescribed lithium (48.3% vs. 28.5%), and clients without SUD were twice as likely to receive divalproex as those with SUD (43% vs. 20.1%) and almost three times as likely to be prescribed an antipsychotic (31.8% vs. 11.4%).

The univariate analysis of differences in the number of antidepressant trials leading to ADM between patients with and without a SUD history showed little difference in the percentage of ADM episodes they experienced (20.7% of trials for those with SUD and 21.4% of trials for those without).

However, using a multivariate regression model of analysis, the authors found that:

  • Patients with a lifetime SUD were five times as likely to experience ADM,
  • The incidence of an antidepressant trial leading to an ADM was greater for clients with Type II or with bipolar disorder not otherwise specified than for Type I,
  • Females were more likely than males to have an episode of ADM in response to an antidepressant trial, and
  • Bupropion was the antidepressant least likely to cause an ADM.

The authors surmise that older research studies excluding people with a SUD might have led to subject pools that underrepresented individuals considerably more likely to experience an ADM than the subjects studied. Additionally, they describe how other confounding factors might have served to hide the effects of having a history of SUD on the likelihood of suffering an ADM.

A discussion of the limitations of their study (e.g., it was non-randomized, non-blind; concomitant therapy may have obscured treatment effect; no measures of adherence to medication regimens) is also given.

Research; Manwani, S. G., Pardo, T. B., Albanese, M. J., Zablotsky, B., Goodwin, F. K., & Ghaemi, S. N. (2006). Substance use disorder and other predictors of antidepressant-induced mania: a retrospective chart review. Journal of Clinical Psychiatry, 67(9), 1341–1345.

Co-Occurring Disorders Research and Resources Monthly Review. The Co-Occurring Center for Excellence (COCE), of the Substance Abuse and Mental Health Services Administration (SAMHSA), Vol. 1, No. 5, December 2006. Readers interested in finding out more about COCE should visit the Web site: http://coce.samhsa.gov/

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          Dual Diagnosis,
Counseling the Mentally Ill Substance Abuser

by Katie Evans, J. Michael Sullivan

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A cohort study of male subjects attending an Alcoholics Anonymous program in India: One-year follow-up for sobriety.

A cohort of subjects in India who completed detoxification treatment and a de-addiction program based on the Alcoholics Anonymous (AA) model were followed-up at 1 year to investigate the factors associated with complete abstinence.

Patients (N = 187 men) who were admitted consecutively to an addiction facility and fulfilled Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for alcohol dependence were recruited for the study.

Patients with major psychopathology were excluded. The final outcome at 1 year was determined by visiting the patients and talking to the families and members of the local AA group.

Of the 187 men initially recruited, 5 were excluded because of major psychopathology, 1 committed suicide, and 7 could not be traced.

Of the 174 patients available for follow-up, 58 (33.3%) remained sober (complete abstinence for the past year) at 1 year.

Patients coming from distant places and those with follow-up workers in their localities fared better than those from the local area and those from towns where there was no one to motivate them to continue with AA meetings.

These variables were significantly associated with sobriety even after adjustment for other confounders using multivariate techniques. A third of the cohort remained sober at 1-year follow-up.

The patients’ initial motivation and continued support once they returned to their communities were associated with sobriety at follow-up.

Research report; Kuruvilla PK; Vijayakumar N; Jacob KS. A cohort study of male subjects attending an Alcoholics Anonymous program in India: One-year follow-up for sobriety. Journal of Studies on Alcohol 65(4):546-549, July 2004.

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Group counseling therapy Treatment response of bipolar and unipolar alcoholics to an inpatient dual diagnosis program

BACKGROUND: Depressed and bipolar alcoholics represent a significant affective subgroup that has a poorer prognosis than either diagnosis alone. To date few systematic treatment programs have been developed to treat dual diagnosis.

METHODS: An inpatient treatment program was developed at St Patrick’s Hospital Dublin to treat dual diagnosis clients with alcohol dependence and either unipolar or bipolar affective disorder.

Clients (N=232) were assessed for depression, anxiety, elation, cravings, drink and drug intake on admission, discharge, 3 and 6 months post-discharge from the program.

RESULTS:

  • In the overall group there was a reduction in number of drinking days and units per drinking day over the study (p<.01).
  • There was a 71.8% complete abstinent rate at 3 months and 55.8% at 6 months in the depression group, non-significantly greater than for the bipolar group at 64.7% and 54.1% respectively.
  • Gamma GT, MCV and craving scores were significantly reduced over time (p<.01).
  • Mania, depression and anxiety inventory scores fell over time in both groups (p<.01).
  • 15-21-year olds were more severely anxious, had higher illicit drug use, and were more likely to relapse to drug use than older clients.
  • Bipolar 1 clients were significantly more likely than bipolar 2 clients to be on mood stabilisers at all follow-up stages (p<.001).

LIMITATIONS: No control group was used.

CONCLUSIONS: There is evidence for efficacy of a specifically designed dual diagnosis inpatient treatment program as both depressed and bipolar alcoholics had significant reductions in all measurements of mood, craving, and alcohol/drug consumption by self report and biological markers, suggesting both diagnoses can be effectively treated together.

Research; J Affect Disord. 2008 Mar;106(3):265-72. Epub 2007 Aug 16. Treatment response of bipolar and unipolar alcoholics to an inpatient dual diagnosis program. Farren CK, Mc Elroy S.

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Abstinent alcoholics can have reduced brain activation without apparent structural damage

  • Heavy alcohol use can lead to structural and functional changes in the brain.
  • New findings show that even when structural damage may not be apparent, brain activation can still be reduced.
  • Researchers refer to this alcohol-induced damage as “latent lesions.”

Researchers know that heavy alcohol intake can lead to structural and functional changes in the brain, but have not been able to establish direct links between these changes and specific cognitive functions. A new examination of memory retrieval among recovering alcoholics has found lower activation than among nonalcoholics in key areas of the brain even in the absence of demonstrable brain structural damage.

Results are published in the September 2007 issue of Alcoholism: Clinical & Experimental Research.

“Even in the alcoholic brain without apparent structural brain changes, some cognitive impairment exists,” said Motoichiro Kato, associate professor in the department of neuropsychiatry at Keio University in Japan. “We believed that the associated functional changes could be visualized by neuroimaging techniques.” Kato is also corresponding author for the study.

“Impairment in different aspects of cognitive, sensory or motor function can arise from problems with impairment in neurochemical systems that enable information to be carried quickly and efficiently between brain regions,” explained Edith V. Sullivan, professor in the department of psychiatry and behavioural sciences at Stanford University School of Medicine. “Such deficits in neurotransmission are not visible with conventional magnetic-resonance imaging methods. However, Doctor Kato used another method, functional magnetic resonance imaging (fMRI), which is sensitive to localized changes in brain-blood volume that occur when an individual engages in a cognitive or motor task. fMRI has been demonstrated to be useful in identifying compromised functional brain systems even in the absence of detectable brain lesions.”

Study authors gave a modified “false recognition task,” a word-matching exercise, to two groups: nine (8 men, 1 woman) alcoholic patients whose onset ages were less than 30 years of age and who were abstinent for an average of 40 months; and nine (7 men, 2 women) community-based “controls” matched on age and education. All participants were scanned with fMRI while performing the task.

Results showed that long-term memory retrieval induced by the task led to lower brain activity in the prefrontal lobes, anterior cingulate cortex, thalamus, and ventral striatum of the alcoholics than the controls.

“Even though both groups of participants performed similarly on the task, what distinguished them were their brain activation levels while engaged in the memory task,” said Sullivan. “The attenuated activations were in brain regions that are known to contribute to goal-directed behaviour, error monitoring, drug-seeking behaviour, and declarative memory, that is, memory for new events.”

“We call this phenomenon ‘latent lesions’ or ‘subclinical pathology’,” said Kato. “To date, brain damages induced by alcohol are known to cause structural changes such as brain atrophy and shrinkage. Conversely, latent lesions mean brain damages not seen in a structural brain examination. Latent lesions may occur without apparent cognitive impairments, so that people continue drinking alcohol without noticing damage to their brain.”

“This functional brain imaging study focused on young to middle-aged adults with a relatively long drinking history and current abstinence period,” added Sullivan. “Other studies of brain structure commonly find that this age group has less evidence for structural brain damage than older alcoholics. But this research group has shown that, in spite of the absence of visible brain lesions or other brain dysmorphology, these younger alcoholics showed differences from controls in brain responsivity to their test stimuli. In other words, alcoholics carry untold liability for brain damage, whether functional or structural.”

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Alcoholics Anonymous after Treatment: Attendance and Abstinence

Follow-up data on 900 inpatients at eight hospital-based chemical dependency treatment centers demonstrate a high correlation between total abstinence 6 months after discharge and weekly attendance at Alcoholics Anonymous during this period.

Almost three-fourths (73%) of the regular attendees remained chemically free, compared with one-third (33%) of the nonattendees.

These data suggest that Alcoholics Anonymous is an appropriate and beneficial aftercare for the majority of treatment inpatients.

Alcoholics Anonymous after Treatment Substance Use & Misuse 1983, Vol. 18, No. 3, Pages 311-318. Norman G. Hoffmann , Patricia Ann Harrison and Carol A. Belille

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The patient who abuses alcohol often is in denial about his addiction and frequently becomes unruly and obstinate as necessary detox measures and treatments are carried out. When the patient is elderly, additional issues can come into play, such as dementia and a poorly functioning immune system caused by years of drinking.

Increasing Numbers

Unfortunately, caring for elderly alcoholics is not an uncommon challenge. Studies find an increasing prevalence of alcoholism among older adults in health care settings. In fact, surveys show 6% to 11% percent of elderly people admitted to hospitals have symptoms of alcoholism, as do 20% in psychiatric wards and 14% in emergency departments.

Alcohol-related admission rates to acute care hospitals also have been found to be similar to those for myocardial infarction, and evidence shows the prevalence of problem drinking in nursing homes is as high as 49%.

Alcoholism itself can be a major concern, but when combined with medical problems associated with aging, care and treatment issues often are compounded. For instance, alcohol consumption causes more falls involving hip fractures in the elderly than would otherwise occur, due to their decreased bone density compared to elderly nonalcoholics.

Elderly drivers who have consumed alcohol are at greater risk for accidents; with age it takes less alcohol to interfere with coordination, judgment and medications.

Increased medication use and age-related liver degeneration means that older adults’ bodies cannot break down the drugs and eliminate them as quickly; this puts them at more risk to suffer adverse reactions. The heart, gastrointestinal tract, immune system and cognitive and motor functions of the brain also are negatively affected by alcohol consumption, and it has been found to increase the risk for some cancers.

Subtle Symptoms

Regardless of age, caring for a patient with alcoholism is a challenge. Unless someone reports the ED patient is an alcoholic, staff often have to look for subtle symptoms, according to Catherine Wilson, RN, a psychiatric nurse clinician at Virginia Commonwealth University Hospital, Richmond. “Most patients are not going to come to you and say they drink every day,” she said.

When a patient shows up in the ED with a fractured hip, sky-high blood alcohol level and is taking out his hostilities on caregivers, the important thing is to keep him from going into withdrawal, Wilson said. Symptoms of this can be a rising temperature, tremors, nausea and vomiting.

With the elderly, these syptoms can mean the patient may be deteriorating rapidly. He can go into delirium tremens, including hallucinations, as well as develop other symptoms—seizures, coma and even death. “People do die from alcohol withdrawal,” Wilson emphasized.

Decision Time

In the ED, many elderly alcoholic patients require surgery after a fall. The attending physician must decide what should come first, the surgery or detoxification. The anesthesiologist, in fact, may make the call to detox first, based on lab results showing magnesium deficiency and/or other abnormal values.

“Obviously, the risks of postponing any surgical intervention must be weighed against the risks of undergoing surgery,” said William J. Lorman, PhD, MSN, PsyNP, chief clinical officer at Livengrin Foundation in Bensalem, Pa., a facility caring for those requiring intervention due to alcohol or drug abuse.

Detox Measures

Wilson stressed, “There is a very fine balance with the elderly, because they tend to react to benzodiazepines [e.g., lorazepam, a commonly used detox drug], more than younger adults. Sometimes phenobarbitol is used instead.”

ED staff also must look for comorbidities such as high blood pressure and other sequelae that tend to accompany prolonged alcohol use.

“If surgery is urgent, the use of benzodiazepines will prevent withdrawal for up to 14 days,” Lorman said.

“Interestingly,” he noted, “the complications reported postoperatively are not secondary to alcohol withdrawal itself, but instead are related to infection, bleeding and delayed wound healing as a result of chronic alcohol misuse.”

By Bette Mooney who is a freelance writer and retired editor at ADVANCE.
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India drunken man New Government Body to Help De-addiction

NEW DELHI (ICNS): A new consultative mechanism at the national level would be set up to advice central and state governments on issues related to drug de-addiction and rehabilitation.

The body, named National Consultative Committee on De-addiction and Rehabilitation (NCCDR), would help address issues connected with drug demand reduction.

It would especially stress education and awareness building, de-addiction and rehabilitation, said an official release from ministry of social justice and empowerment said on July 16.

The ministry has been extending financial assistance to over 350 non-Governmental Organizations for running 41 counselling centers and 401 de-addiction centers in the country.

The ministry has also taken up regular awareness generation programs to tackle issue of alcoholism and drug abuse in the country.

Meira Kumar, Minister for Social Justice and Empowerment would chair the body, while Subbulakshmi Jagadeesan, Minister of State for Social Justice and Empowerment would be the vice chairperson.

The functions of the new committee would be to advise Central and State Governments to the entire gamut of issues related to drug abuse prevention, de-addiction, rehabilitation and harm reduction.

The Ministry of Social Justice and Empowerment has been implementing a scheme for prevention of alcoholism and substance (drugs) abuse.

Full story at; The Indian Catholic

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Inverted Light

Persistent influence of social networks and Alcoholics Anonymous on abstinence

The role of changes in Alcoholics Anonymous (AA) involvement and social networks in relation to abstinence following substance abuse treatment is studied.

Specifically, the role of AA and network support for abstinence are examined in relation to their effect on changes in abstinence states between follow-ups. Study sites were 10 representative public and private alcohol treatment programs in a northern California county.

A recruitment of 367 men and 288 women seeking treatment were interviewed at intake and re-interviewed 1 and 3 years later to collect information about alcohol consumption, dependence symptoms, social support for reducing drinking, number of heavy drinkers in the social network and AA involvement.

Significant predictors of 90-day abstinence at both the 1- and 3-year follow-up interviews included AA involvement in the last year, percentage of heavy or problem drinkers in the social network, percentage encouraging alcohol reduction and AA-based support for reducing drinking.

Panel models estimated an increase in AA participation between 12 and 36 months post-treatment increased the odds of abstinence at 3 years by 35% above those at 12 months.

The only significant mediator of AA’s effect on abstinence was the number of AA-based contacts supporting reduced drinking, which reduced the magnitude of the relationship by 16%. It is concluded that AA involvement and the type of support received from AA members were consistent contributors to abstinence 3 years following a treatment episode.

Research report; Bond, J.; Kaskutas, L.A.; Weisner, C. Persistent influence of social networks and Alcoholics Anonymous on abstinence. Journal of Studies on Alcohol, 64(4):579-588, 2003.

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